Death is the only physician, the shadow of his valley the only journeying that will cure us of age and the gathering fatigue of years. Discuss

Until the day when God shall deign to reveal the future to man, all human wisdom is summed up in these two words, —'Wait and hope'.

Nature is a mutable cloud which is always and never the same.

Faith, n.: Belief without evidence in what is told by one who speaks without knowledge, of things without parallel. Discuss

It takes people a long time to learn the difference between talent and genius, especially ambitious young men and women.

Friends are an aid to the young, to guard them from error; to the elderly, to attend to their wants and to supplement their failing power of action; to those in the prime of life, to assist them to noble deeds.

Interessant onderzoek - wellicht iets te hoopvol, ik geloof het pas als ik het zie.
The international team of researchers based Newcastle University have reportedly unlocked the secret as to how and why living cells grow old by discovering the biochemical pathway involved in ageing.
The study, together with German experts from the University of Ulm, could lead to a “much better chance of making a successful attack on age-related diseases”.

The results, published by the journal Molecular Systems Biology, also showed that when an ageing cell detects serious DNA damage that could be caused by general wear from life it sent out internal signals to the brain.
These distress signals trigger the cell’s “mitochondria”, or its tiny energy-producing power packs, to make “free radical” molecules.
This in turn informs the cell to either to destroy itself or stop dividing which is aimed at avoiding damaged DNA that can cause cancer.
It also reportedly plays down the role of telomeres, which are the protective tips on the ends of human chromosomes, which gradually become shorter as humans age.

Ook interessant is dat de rol van telomeren in het verouderingsproces hier wat minder belangrijk wordt geacht.

“There has been a huge amount of speculation about how blocking telomere erosion might cure ageing and age-related diseases,” Prof Kirkwood said. “The telomere story has over-promised and the biology is more complicated.

Lees het hele artikel.

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An interesting issue of WUZ, a magazine devoted to Jean Paul - and especially his schoolmaster Wuz, who - like the Duke of Gloucester - preferred thin books over "damned fat square books".
So, WUZ apparently always issues small, thin booklets with only a few pages. I only got to know the magazine when the publisher, Armin Elhardt, offered me to send me volume 19, devoted to Albert Lortzing and written by Lortzing's greatest fan - not to say zealot: Jürgen Lodemann, as a present. A great gift - thank you mr. Elhardt!.
I know mr. Lodemann personally, I've met him, I've heard him lecturing on Lortzing in Detmold (2001) and Leipzig (2009),and I've read his "damned fat" book on Lortzing: "Gaukler und Musiker" (2000). And he gave me permission to publish his great essay "Nun kommt der Freiheit grosser Morgen" (on Lortzing's opera "Regina") on this website.
Now this small book is another example of Lodemann's persuasive style: in nineteen short statements mr. Lodemann explains why Lortzing always has been important to opera culture and still should be important to us. Beautifully illustrated with drawings by Peter Schmidt, that make this issue a must-have for the Lortzing connoisseur and the collector of Lorzingiana. But also the superficially interested reader will pick it up to read and re-read it again and again, or just to browse through the pages.
WUZ is published in a limited edition, which is a shame. The only obstacle I can think of for you, my dear reader, is the language: WUZ is entirally written in German. But, thinking about it, when you're interested in German culture you can't have a serious problem with the language.

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Per 1 maart begin ik als dirigent van Vocal Group Kwasi Kloos. In het verleden heb ik al eens voor Kwasi Kloos gearrangeerd en ook ingevallen als dirigent bij het koorfestival in Almelo vorig jaar 21 maart, waar we de eerste prijs in de categorie grote ensembles/kleine koren wonnen.

Man is more courageous, pugnacious, and energetic than woman, and has a more inventive genius. His brain is absolutely larger, but whether or not proportionally to his larger body, has not, I believe, been fully ascertained. Discuss

It opens the lungs, washes the countenance, exercises the eyes, and softens down the temper...; so cry away.

A stiff apology is a second insult... The injured party does not want to be compensated because he has been wronged; he wants to be healed because he has been hurt.

Excess of joy is harder to bear than any amount of sorrow. Discuss

Kenneth Hayworth heeft een interessante website gemaakt, die weliswaar niet rechtstreeks over cryogene suspensie gaat maar met betrekking tot de onderwerpen raakt aan zaken die ook voor cryonisten belangrijk zijn: Brain Preservation en Mind Uploading.

Bovendien - on gekissebis te voorkomen - gaat de website uiteindelijk eigenlijk vooral over het ultieme overleven, het overwinnen van de dood en dat is natuurlijk eigenlijk het doel van de cryonist, de suspensie is slechts een middel.

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The world knows of Rosa Parks because of a single, simple act of dignity and courage that struck a lethal blow to the foundations of legal bigotry.

We know our friends by their defects rather than by their merits.

Nice Social Media counter by Gary Hayes:

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A new tool for social bookmarking and sharing the information you find on the Web: Diigo. It promises to offer a lot of tools to archive everything you find interesting enough to remember. And to annotate: you can highlight and add sticky notes to websites.

More Diigo-videos at Vimeo:

Is Diigo better than other services, like Evernote (“Welcome to your notable world. Use Evernote to save your ideas, things you see, and things you like. Then find them all on any computer or device you use”)? A recent post at the Dutch Lifehacker Blog showed me that there are enough Evernote Life-Hacks to invest a little more in exploring Evernote – until now I’ve only used it as a bookmark-tool. So, I’m not sure about Diigo yet, but of course I will give it a try.
Other services that offer comparable features: Twine (“organize, share, discover”) and Zotero (“gather, organize, and analyze” “See it. Save it. Sort it. Search it. Cite it.”). And of course Delicious (“Keep, share, and discover”). Like Evernote, Diigo offers you the opportunity to import your delicious bookmarks and synchronize them.

©2010 Kuehleborn's World. All Rights Reserved.

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A cynic is a man who knows the price of everything but the value of nothing. Discuss

When a true genius appears in the world, you may know him by this sign, that the dunces are all in confederacy against him.